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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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25 hot topic(s) found with the query "Crohn's disease"

Newer Biologic and Small-Molecule Therapies for Inflammatory Bowel Disease.
Baumgart Daniel C et al. The New England journal of medicine 2021 9 (14) 1302-1315 (Posted: Sep 30, 2021 7AM)

An improved understanding of the complex pathogenesis of Crohn’s disease and ulcerative colitis has led to a therapeutic strategy focused on hard end points (e.g., clinical and endoscopic remission)5 and precise molecular targeting of inflammatory cascades. Compound selection, sequencing, combination, monitoring, and adjustment are part of a continuum of decisions that take into consideration the patient’s history, the disease phenotype, coexisting conditions, the patient’s goals and preferences, disease activity, treatment efficacy, and side effects, all of which may change over time.

A molecular connection hints at how a genetic risk factor drives Crohn’s disease
S Plevy, Nature News, April 19, 2021 (Posted: Apr 21, 2021 7AM)

Mutations of the NOD2 gene are risk factors for Crohn’s disease. Many aspects of how they contribute to the condition are unknown. The discovery of cell populations that are involved suggests new therapeutic options.

Why 100,000 poop photos may bring the next big thing in fitness tracking-New crowdsourcing initiative aims to build an app that tracks users' gastrointestinal health
S Salzman, NBC News, October 28, 2019 (Posted: Oct 30, 2019 9AM)

A computer scientist is working to build the world’s largest database of human stool photos — up to 100,000 in all. The images will be used to teach an artificial intelligence to tell the difference between stool that’s consistent with good health and stool that could be evidence of gastrointestinal ailments like irritable bowel syndrome or Crohn’s disease.

Development and Validation of Machine Learning Models in Prediction of Remission in Patients With Moderate to Severe Crohn Disease
AK Waljee et al, JAMA Network Open, May 10, 2019 (Posted: May 11, 2019 0PM)

Microbial network disturbances in relapsing refractory Crohn's disease.
Yilmaz Bahtiyar et al. Nature medicine 2019 Jan (Posted: Jan 25, 2019 9AM)

Genetic risk variants as therapeutic targets for Crohn's disease.
Gabbani Tommaso et al. Expert opinion on therapeutic targets 2017 Apr (4) 381-390 (Posted: Apr 17, 2017 9AM)

DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis.
McDermott Edel et al. Journal of Crohn's & colitis 2016 Jan (1) 77-86 (Posted: Jan 25, 2016 10AM)

Microbiota in Inflammatory Bowel Disease Pathogenesis and Therapy: Is It All About Diet?
Serban Daniela Elena et al. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 2015 Dec (6) 760-79 (Posted: Jan 25, 2016 10AM)

Inflammatory Bowel Disease: Genetics, Epigenetics, and Pathogenesis.
Loddo Italia et al. Frontiers in immunology 2015 551 (Posted: Jan 25, 2016 10AM)

Genome-Wide Copy Number Variation Scan Identifies Complement Component C4 as Novel Susceptibility Gene for Crohn's Disease.
Cleynen Isabelle et al. Inflammatory bowel diseases 2015 Nov (Posted: Jan 25, 2016 10AM)

Genetics of inflammatory bowel disease from multifactorial to monogenic forms.
Bianco Anna Monica et al. World journal of gastroenterology 2015 Nov (43) 12296-310 (Posted: Jan 25, 2016 10AM)

Host-microbiome interaction in Crohn's disease: A familiar or familial issue?
Michielan Andrea et al. World journal of gastrointestinal pathophysiology 2015 Nov (4) 159-68 (Posted: Jan 25, 2016 10AM)

Mechanisms of Microbe-Host Interaction in Crohn's Disease: Dysbiosis vs. Pathobiont Selection.
Buttó Ludovica F et al. Frontiers in immunology 555 (Posted: Dec 07, 2015 5PM)

Extensive Modulation of the Fecal Metagenome in Children With Crohn's Disease During Exclusive Enteral Nutrition.
Quince Christopher et al. The American journal of gastroenterology 2015 Nov (Posted: Nov 05, 2015 4PM)

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
I Cleymen et al. Lancet, October 2015 (Posted: Oct 19, 2015 6AM)

Understanding inflammatory bowel disease via immunogenetics.
de Lange Katrina M et al. Journal of autoimmunity 2015 Aug (Posted: Oct 16, 2015 2PM)

Nutritional Modulation of Gene Expression: Might This be of Benefit to Individuals with Crohn's Disease?
Ferguson Lynnette R et al. Frontiers in immunology 2015 467 (Posted: Oct 16, 2015 2PM)

Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn’s Disease
JD Lewis et al, Cell Host and Microbe, October 14, 2015 (Posted: Oct 16, 2015 2PM)

Inflammatory bowel diseases: ulcerative colitis and Crohn’s disease
Brand (Posted: Oct 16, 2015 2PM)

Body Mass Index, Genetic Susceptibility, and Risk of Complications Among Individuals with Crohn's Disease.
Pringle Patricia L et al. Inflamm. Bowel Dis. 2015 Jul 15. (Posted: Jul 20, 2015 2PM)

Fecal microbial transplant effect on clinical outcomes and fecal microbiome in active Crohn's disease.
Suskind David L et al. Inflamm. Bowel Dis. 2015 Mar (3) 556-63 (Posted: Mar 07, 2015 5PM)

Deep resequencing of 131 Crohn's disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants.
Hong Sung Noh et al. Gut 2015 Mar 2. (Posted: Mar 07, 2015 5PM)

Pathogenesis of Crohn's disease: Bug or no bug.
Bosca-Watts Marta Maia et al. World J Gastrointest Pathophysiol 2015 Feb 15. (1) 1-12 (Posted: Feb 25, 2015 2PM)

Crohn's disease of the esophagus
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Pediatric Crohn's disease
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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